Host: Rabbit
Target Protein: NOCT
IR: Immunogen Range:231-330/431
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 25819
Swiss Prot: Q9UK39
Source: KLH conjugated synthetic peptide derived from human Nocturnin:231-330/431
Purification: affinity purified by Protein A
Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background: Nocturnin is a 431 amino acid circadian deadenylase protein that is expressed in a broad range of tissues with greatest abundance in the liver, kidney and testis. Nocturnin plays a role in circadian regulation as well as diet-induced obesity. The mRNA abundance of Nocturnin exhibits circadian rhythmicity, peaking after dusk in photoreceptors, spleen, heart, kidney and liver. Nocturnin is thought to be responisble for turning off genes that are involved in circadian regulation. In Xenopus retinal photoreceptor cells, the rhythmic regulation of Nocturnin is thought to be controlled by phosphorylated CREB. Mice lacking Nocturnin remain lean on high fat diets with a reduction in visceral fat, which suggests that this protein may also be responsible for lipid metabolism and fat storage.
Size: 100ul
Concentration: 1mg/ml
Applications: WB=1:500-2000,ELISA=1:5000-10000
Cross Reactive Species: Human,Mouse,Rat
For research use only. Not intended for diagnostic or therapeutic use.