Host: Rabbit

Target Protein: Phospho-GRB10 (Tyr67)

IR: Immunogen Range:SL(p-Y)SA

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 2887

Swiss Prot: Q13322

Source: KLH conjugated Synthesised phosphopeptide derived from human GRB10 around the phosphorylation site of Tyr67:SL(p-Y)SA 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: GRB 10 belongs to a small family of adapter proteins that interact with receptor tyrosine kinases and signaling molecules. In particular, GRB 10 interacts with insulin receptors and insulin-like growth-factor receptors. Alternatively spliced transcript variants encoding different isoforms have been identified: overexpression of some of them inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner.