Host: Rabbit

Target Protein: HIF Prolyl Hydroxylases

IR: Immunogen Range:201-300/502

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 54681

Swiss Prot: Q9NXG6

Source: KLH conjugated synthetic peptide derived from human HIFPH4:201-300/502 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex.