Host: Rabbit

Target Protein: Hoxb3

IR: Immunogen Range:201-300/431

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 3213

Swiss Prot: P14651

Source: KLH conjugated synthetic peptide derived from human Hoxb3:201-300/431 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: HOX genes play a fundamental role in the development of the vertebrate central nervous system, heart, axial skeleton, limbs, gut, urogenital tract and external genitalia. There are multiple transcripts of the Hoxb3 gene, and the anterior boundaries of its expression vary at different stages of development. Hoxb3 plays a role in the proliferation and differentiation of both early myeloid and lymphoid developmental pathways. Hoxb3 also has overlapping function in mediating the migration of pharyngeal organ primordia and is expressed in very restricted domains in the future hindbrain. Hoxb6 controls the generation, proliferation and survival of erythroid progenitor cells. The Hoxb6 protein is expressed in the suprabasal layer of the early developing epidermis and throughout the upper layers of late fetal and adult human skin. Hoxb6 is cytoplasmically expressed throughout fetal epidermal development, but displays nuclear expression in normal adult skin. Hoxb6 protein also has nuclear expression in hyperproliferative skin conditions, but appears to be localized in the cytoplasm in basal and squamous cell carcinomas. Hoxb6 genes are also expressed in normal adult lung.