Host: Rabbit

Target Protein: ENTPD8

IR: Immunogen Range:21-120/495

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 377841

Swiss Prot: Q5MY95

Source: KLH conjugated synthetic peptide derived from human ENTPD8:21-120/495 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: Members of the ecto-nucleoside triphosphate diphosphohydrolase (eNTPDase) protein family are glycosylated enzymes that hydrolyze nucleoside 5’-triphosphates and 5’-diphosphates in extracellcular space. The enzymatic activities of eNTPDase are dependent on cations such as magnesium and calcium. Members of this protein family differ in their affinities for triphosphates versus diphosphates as substrate material. NTPDase8, also known as ENTPD8 (ectonucleoside triphosphate diphosphohydrolase 8) or E-NTPDase 8, is a 495 amino acid multi-pass membrane protein belonging to the GDA1/CD39 NTPase family. As a canalicular ectonucleoside NTPDase, NTPDase8 is involved in hepatic NTPDase activity and helps concentrate extracellular nucleotides. NTPDase8 binds calcium as a cofactor, becomes glycosylated following translation and exists as two alternatively spliced isoforms.