Host: Rabbit
Target Protein: HIF Prolyl Hydroxylases
IR: Immunogen Range:201-300/502
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 54681
Swiss Prot: Q9NXG6
Source: KLH conjugated synthetic peptide derived from human HIFPH4:201-300/502
Purification: affinity purified by Protein A
Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background: Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex.
Size: 50ul
Concentration: 1mg/ml
Applications: WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
Cross Reactive Species: (predicted: Human,Mouse,Rat,Pig,Horse)
For research use only. Not intended for diagnostic or therapeutic use.