Host: Rabbit

Target Protein: XAB2

IR: Immunogen Range:65-160/855

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 56949

Swiss Prot: Q9HCS7

Source: KLH conjugated synthetic peptide derived from human PBP/HCNP:65-160/855 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: XAB2 protein (XPA binding protein 2) was first identified through its interaction with XPA, a key factor in nucleotide excision repair pathways. XAB2 therefore appears to be involved in transcription coupled DNA repair and transcription. Immunoprecipitation experiments have also demonstrated that a fraction of XAB2 interacts with the transcription coupled repair specific proteins CSA and CSB as well as with RNA polymerase II. Microinjection experiments with XAB2 antibodies resulted in the inhibition of both transcription coupled repair and transcription.