Host: Rabbit
Target Protein: KDM5B
IR: Immunogen Range:65-165/1544
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 10765
Swiss Prot: Q9UGL1
Source: KLH conjugated synthetic peptide derived from human KDM5B/PLU1/Jarid1B:65-165/1544
Purification: affinity purified by Protein A
Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background: Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.
Size: 50ul
Concentration: 1mg/ml
Applications: WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500, Flow-Cyt=3ug/test, ELISA=1:5000-10000
Cross Reactive Species: Human,Rat (predicted: Mouse,Chicken,Dog,Pig,Cow,Horse,GuineaPig)
For research use only. Not intended for diagnostic or therapeutic use.