Host: Rabbit

Target Protein: Cyclophilin B

IR: Immunogen Range:31-65/216

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 5479

Swiss Prot: P23284

Source: KLH conjugated synthetic peptide derived from human Cyclophilin B:31-65/216 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Involvement in disease; Defects in PPIB are the cause of osteogenesis imperfecta type 9 (OI9).OI9 is a connective tissue disorder characterized by bone fragility, low bone mass and bowing of limbs due to multiple fractures. Short limb dwarfism and blue sclerae are observed in some but not all patients.
Sequence similarities; Belongs to the cyclophilin-type PPIase family. PPIase B subfamily. Contains 1 PPIase cyclophilin-type domain.