Host: Rabbit
Target Protein: PDE4D
IR: Immunogen Range:401-550/809
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 5144
Swiss Prot: Q08499
Source: KLH conjugated synthetic peptide derived from human PDE4D:401-550/809
Purification: affinity purified by Protein A
Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background: Cyclic AMP-dependent phosphodiesterase type D (PDE4D) family is comprise of 5 variants (PDE4D1, D2, D3, D4 and D5). One or more PDE4D subtype variants are ubiquitously present in all mammalian cells. In CNS all five PDE4D subtype variants are expressed in varying ratios and their activity is regulated in tandem with GPCRs stimulation. Peripheral tissues also exhibit differential expression of PDE4D variants. PDE4D1/D2 mRNA levels rise in response to an increase in cAMP. Short term regulation of PDE4D variants involved PKA, MAP kinases and Erk2 phosphorylation that results in rapid change in their enzymatic activities. Other regulatory mechanism involved protein protein interactions with cytoskeletal scaffolding proteins.
Size: 100ul
Concentration: 1mg/ml
Applications: WB=1:500-2000, Flow-Cyt=1μg/Test, ELISA=1:5000-10000
Cross Reactive Species: Mouse,Rat (predicted: Human,Dog,Pig,Cow,Horse,Rabbit)
For research use only. Not intended for diagnostic or therapeutic use.