Host: Rabbit

Target Protein: BBC3/PUMA, Alexa Fluor 680 conjugated

IR: Immunogen Range:131-180/193

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 27113

Swiss Prot: Q96PG8

Source: KLH conjugated synthetic peptide derived from human BBC3:131-180/193 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]