Host: Mouse

Target Protein: human/mouse ZAP-70/PE

IR: Immunogen Range:

Clonality: Monoclonal

Isotype: Mouse IgG1

Entrez Gene: 7535

Swiss Prot: P43403

Source: : 

Purification: Affinity purified by Protein G

Storage: 0.01M PBS, 0.5%BSA, 0.03% Proclin300 Store at 2-8℃. Protect from light. Avoid freezing.

Background: This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]