Host: Rat

Target Protein: mouse CD11a/PE-Cy7

IR: Immunogen Range:

Clonality: Monoclonal

Isotype: Rat IgG2a, k

Entrez Gene: 16408

Swiss Prot: P24063

Source: : 

Purification: Affinity purified by Protein G

Storage: 0.01M PBS, 0.5%BSA, 0.03% Proclin300 Store at 2-8℃. Protect from light. Avoid freezing.

Background: ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]