Host: Rat

Target Protein: mouse CD18/PE

IR: Immunogen Range:

Clonality: Monoclonal

Isotype: Rat IgG2a, k

Entrez Gene: 16414

Swiss Prot: P11835

Source: : 

Purification: Affinity purified by Protein G

Storage: 0.01M PBS, 0.5%BSA, 0.03% Proclin300 Store at 2-8℃. Protect from light. Avoid freezing.

Background: Enables amyloid-beta binding activity and complement component C3b binding activity. Contributes to cargo receptor activity. Involved in several processes, including cellular response to low-density lipoprotein particle stimulus; endocytosis; and positive regulation of leukocyte adhesion to vascular endothelial cell. Acts upstream of or within several processes, including activated T cell proliferation; integrin-mediated signaling pathway; and leukocyte migration. Located in external side of plasma membrane and membrane raft. Part of integrin alphaM-beta2 complex. Is expressed in several structures, including alimentary system; genitourinary system; heart and pericardium; hemolymphoid system; and nervous system. Used to study leukocyte adhesion deficiency 1 and psoriasis. Human ortholog(s) of this gene implicated in coronary restenosis; leukocyte adhesion deficiency; and leukocyte adhesion deficiency 1. Orthologous to human ITGB2 (integrin subunit beta 2). [provided by Alliance of Genome Resources, Apr 2022]