Host: Rabbit
Target Protein: TYROBP
IR: Immunogen Range:
Clonality:
Isotype: IgG
Entrez Gene: 7305
Swiss Prot: O43914
Source: KLH conjugated synthetic peptide derived from human TYROBP:
Purification: affinity purified by Protein A
Storage: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background: This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010]
Size: 50ul
Concentration: 1mg/ml
Applications: WB=1:300-500, IHC-P=1:100-500
Cross Reactive Species: (predicted: Human)
For research use only. Not intended for diagnostic or therapeutic use.