Host: Rabbit
Target Protein: AMHR2
IR: Immunogen Range:18-149/573
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 269
Swiss Prot: Q16671
Source: Recombinant human MISRII protein:18-149/573
Purification: affinity purified by Protein A
Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background: MISR II is a 573 amino acid protein encoded by the human gene AMHR2. MISR II belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily and contains one protein kinase domain. Upon ligand binding, MISR II forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. These type II receptors phospho-rylate and activate type I receptors which autophosphorylate, then bind and activate Smad transcriptional regulators. MISR II also acts as a receptor for anti-Muellerian hormone. Defects in AMHR2 are the cause of persistent Muellerian duct syndrome type 2 (PMDS-2). PMDS-2 is a form of male pseudo-hermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males.
Size: 200ul
Concentration: 1mg/ml
Applications: IHC-P=1:100-500, ELISA=1:5000-10000
Cross Reactive Species: Rat (predicted: Mouse,Human)
For research use only. Not intended for diagnostic or therapeutic use.