Host: Rabbit
Target Protein: TAB1, Alexa Fluor 680 conjugated
IR: Immunogen Range:351-450/504
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 10454
Swiss Prot: Q15750
Source: KLH conjugated synthetic peptide derived from human MAP3K7IP1/TAB1:351-450/504
Purification: affinity purified by Protein A
Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background: TAB1 was identified as a regulator of the MAP kinase kinase kinase TAK1/MAP3K7, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta and members of the Toll IL 1R (TIR) superfamily, thus acting as an intermediate in both proliferative and innate and adaptive immune responses. This protein, together with either TAB2 or TAB3, activates TAK1 kinase in response to upstream signals. It has been shown that the C terminal portion of TAB1 is sufficient for binding and activation of TAK1, while a portion of the N terminus acts as a dominant negative inhibitor of TGF beta, demonstrating how this protein can function as a mediator between TGF beta receptors and TAK1.
Size: 100ul
Concentration: 1mg/ml
Applications:
Cross Reactive Species:
For research use only. Not intended for diagnostic or therapeutic use.