Host: Rabbit

Target Protein: Phospho-TAK1(Thr184 + Thr187), Alexa Fluor 750 conjugated

IR: Immunogen Range:IQ(p-T)HM(p-T)NN

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 6885

Swiss Prot: O43318

Source: KLH conjugated Synthesised phosphopeptide derived from human TAK1 around the phosphorylation site of Thr184/187:IQ(p-T)HM(p-T)NN 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]