Host: Rabbit

Target Protein: IL-1 beta

IR: Immunogen Range:

Clonality:

Isotype: IgG

Entrez Gene: 3553

Swiss Prot: P01584

Source: KLH conjugated synthetic peptide derived from human IL-1 beta: 

Purification: affinity purified by Protein A

Storage: 0.01M TBS (pH7.4)with 0.05% BSA, 40% Glycerol, 0.05% Sodium Azide. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008].