Host: Rabbit
Target Protein: Beclin 1
IR: Immunogen Range:201-330/450
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 8678
Swiss Prot: Q14457
Source: KLH conjugated synthetic peptide derived from human BECN1:201-330/450
Purification: affinity purified by Protein A
Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background: Beclin 1 is the first identified mammalian gene to mediate autophagy and also has tumor suppressor and antiviral function. Autophagy, a process of bulk protein degradation through an autophagosomic lysosomal pathway, is important for differentiation, survival during nutrient deprivation, and normal growth control, and is often defective in tumor cells. Beclin 1 was originally isolated in a yeast two hybrid screen to identify Bcl 2 binding partners and maps to a tumor susceptibility locus on human chromosome 17q21 that is frequently monoallelically deleted in human breast, ovarian and prostate cancer. Beclin 1 encodes an evolutionarily conserved 52kDa coiled coil protein that is expressed in human muscle, epithelial cells and neurons.
Size: 50ul
Concentration: 1mg/ml
Applications: WB=1:500-2000, IHC-P=1:100-500, Flow-Cyt=1μg/Test, ELISA=1:5000-10000
Cross Reactive Species: Rat,Mouse,Human (predicted: Bovine,Pig)
For research use only. Not intended for diagnostic or therapeutic use.