Host: Rabbit

Target Protein: IGF2R/M6PR

IR: Immunogen Range:2201-2400/2491

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 3482

Swiss Prot: P11717

Source: KLH conjugated synthetic peptide derived from human IGF2R:2201-2400/2491 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.