bs-6760R [Primary Antibody]
Rabbit  Anti-KCNQ1  Polyclonal Antibody
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Host: Rabbit

Target Protein: KCNQ1

IR: Immunogen Range:501-600/676

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 3784

Swiss Prot: P51787

Source: KLH conjugated synthetic peptide derived from human KCNQ-1:501-600/676 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current in CHO cells in which cloned KCNQ1/KCNE1 channels were coexpressed with M1 muscarinic receptors. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in cystic fibrosis and pathologically stimulated in cholera and other forms of secretory diarrhea. Involvement in disease:

Size: 100ul

Concentration: 1mg/ml

Applications: WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500, ELISA=1:5000-10000

Cross Reactive Species: (predicted: Human,Mouse,Rat,Chicken,Dog,Cow)

For research use only. Not intended for diagnostic or therapeutic use.

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