Host: Rabbit

Target Protein: CCKBR

IR: Immunogen Range:301-400/447

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 887

Swiss Prot: P32239

Source: KLH conjugated synthetic peptide derived from human Gastrin receptor:301-400/447 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent mechanism.