bs-1970R [Primary Antibody]
Rabbit  Anti-LAMP1  Polyclonal Antibody
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Host: Rabbit

Target Protein: LAMP1

IR: Immunogen Range:301-417/417

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 3916

Swiss Prot: P11279

Source: KLH conjugated synthetic peptide derived from human LAMP-1:301-417/417 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: Lysosome associated membrane protein (LAMP1), also known as lgp120 or lgpA, is a type 1 integral membrane protein that is transported from trans Golgi networks to endosomes and then lysosomes. Upon cell activation, LAMP1 transfer to the plasma membrane is dependent on a carboxyl terminal tyrosine based motif (YXXI). Perturbation in the spacing between the tyrosine based motif relative to the membrane abolishes lysosome localization of LAMP1. This mutant protein then cycles between the plasma membrane and the endosome. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore they are possibly involved in the adhesion of PBMCs to the site of inflammation.

Size: 100ul

Concentration: 1mg/ml

Applications: WB=1:200-1000, IHC-P=1:100-500, IHC-F=1:100-500, ICC=1:100-500, IF=1:100-500, ELISA=1:5000-10000

Cross Reactive Species: Rat,Human (predicted: Pig,Mouse)

For research use only. Not intended for diagnostic or therapeutic use.

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