Host: Rabbit
Target Protein: CACNA1S
IR: Immunogen Range:901-1000/1873
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 779
Swiss Prot: Q13698
Source:
KLH conjugated synthetic peptide derived from human CACNA1S:901-1000/1873
Purification: affinity purified by Protein A
Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1S gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle.
Size: 100ul
Concentration: 1mg/ml
Applications: IHC-P=1:100-500, ELISA=1:5000-10000
Cross Reactive Species: Mouse,Rat (predicted: Human,Pig,Cow,Rabbit)
For research use only. Not intended for diagnostic or therapeutic use.