Host: Rabbit

Target Protein: ATP7B

IR: Immunogen Range:1351-1465/1465

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 540

Swiss Prot: P35670

Source: KLH conjugated synthetic peptide derived from human ATP7B:1351-1465/1465 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: ATP7b is an important protein for copper transport and elimination of excess copper from the body. ATP7b transports metals in and out of cells using ATP. There are 3 known isoforms of the ATP7b gene; A is found in the liver, kidney, and brain, the shorter form B is found in brain tissue, and the third isoform, known as WND/140 KDA is found in mitochondria. Mutations in the ATP7b gene can cause Wilson's disease, an inherited disorder causing copper poisoning in the brain and liver.