Host: Rabbit

Target Protein: Alpha-synuclein (nitro-Tyr39)

IR: Immunogen Range:VL(nitrated-Y)VG

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 6622

Swiss Prot: P37840

Source: KLH conjugated Synthesised nitrylpeptide derived from human SNCA around the nitrosation site of Tyr39:VL(nitrated-Y)VG 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016].