bs-11676R [Primary Antibody]
Rabbit  Anti-UCHL3  Polyclonal Antibody
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Host: Rabbit

Target Protein: UCHL3

IR: Immunogen Range:133-230/230

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 7347

Swiss Prot: P15374

Source: KLH conjugated synthetic peptide derived from human UCHL3:133-230/230 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: UCH-L1 is a member of a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to generate the ubiquitin monomer. Expression of UCH-L1 is highly specific to neurons and to cells of the diffuse neuroendocrine system and their tumors. UCH-L1 is expressed in brain neurons. Examination of specific brain regions reveals expression in all areas tested, particularly in the substantia nigra. UCH-L1 represents 1 to 2% of total soluble brain protein. Its occurrence in Lewy bodies and its function in the proteasome pathway make it a compelling candidate gene in Parkinson disease. The gene which encodes UCH-L1 maps to human chromosome 4p14. The 230 amino acid human UCH-L3 protein is 54% identical to that of UCH-L1. UCH-L3 is the predominant thiol protease and has high-affinity binding sites for ubiquitin.

Size: 200ul

Concentration: 1mg/ml

Applications: WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, ICC=1:100-500, IF=1:100-500, ELISA=1:5000-10000

Cross Reactive Species: Rat (predicted: Human,Mouse,Chicken)

For research use only. Not intended for diagnostic or therapeutic use.

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