Host: Rabbit
Target Protein: Phospho-EEF2k (Ser359)
IR: Immunogen Range:CG(p-S)P
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 29904
Swiss Prot: O00418
Source: KLH conjugated Synthesised phosphopeptide derived from human EEF2k around the phosphorylation site of Ser359:CG(p-S)P
Purification: affinity purified by Protein A
Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background: Eukaryotic elongation factor 2 kinase (EEF2k) previously known as Ca2+/calmodulin dependent protein kinase III, is an abundant cytoplasmic protein highly specific for elongation factor 2 (eEf2). Phosphorylation of eEF2 by eEF2 kinase on specific threonine residues results in the inactivation of eEF-2 and in termination of mRNA translation. The activity of eEF2 kinase is not only dependent upon Ca2+ ions, calmodulin (CaM) and insulin, but is also regulated both negatively and positively via phosphorylation by different protein kinases (AMPK, S6K1, p90 RSK). There is also evidence that eEF-2 phosphorylation is involved in the regulation of cell cycle progression, cellular differentiation, oogensis and malignant tumors.
Size: 200ul
Concentration: 1mg/ml
Applications: ELISA=1:5000-10000
Cross Reactive Species: (predicted: Human,Mouse,Rat,Chicken,Dog,Horse,Rabbit,Sheep)
For research use only. Not intended for diagnostic or therapeutic use.