Host: Rabbit

Target Protein: Caspase-6 subunit p11

IR: Immunogen Range:181-293/293

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 839

Swiss Prot: P55212

Source: KLH conjugated synthetic peptide derived from human Caspase-6 subunit p11:181-293/293 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: Caspase-6 Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death. Subunit is compose of heterodimer of a18 kDa (p18) and a 11 kDa (p11) subunit. Subcellular location at cytoplasmic. Cleavages by CPP32, caspase-8 or -10 generate the two active subunits. It belongs to the peptidase C14 family.