Host: Rabbit

Target Protein: IFNA14

IR: Immunogen Range:121-189/189

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 3448

Swiss Prot: P01570

Source: KLH conjugated synthetic peptide derived from human IFNA14:121-189/189 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: The genes encoding type I interferons (IFNs), which include 14 IFN-alpha genes, 1 IFN-beta gene, 1 IFN-omega (also known as IFN-alpha II1) gene, and a number of IFN-omega pseudogenes, are clustered on human chromosome 9. Interferon-alpha and -beta are cytokines that are widely known to induce potent antiviral activity. They exert a variety of other biological effects, including antitumor and immunomodulatory activities and are increasingly used clinically to treat a range of malignancies, myelodysplasias and autoimmune diseases. IFN-omega is antigenically different from human IFN-alpha, IFN-beta or IFN-gamma, but is a component of natural mixtures of IFN species produced by virus-induced leukocytes or Burkitt's lymphoma cells. The type I interferon receptor (IFN-alpha R) interacts with IFN-alpha, IFN-beta and IFN-omega, and seems to be a multisubunit receptor.