Host: Rabbit

Target Protein: KIAA1462

IR: Immunogen Range:1251-1359/1359

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 57608

Swiss Prot: Q9P266

Source: KLH conjugated synthetic peptide derived from human KIAA1462:1251-1359/1359 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: KIAA1462 is a 1,359 amino acid protein that colocalizes with VE-Cadherin specifically in endothelial cells and not epithelial cells. KIAA1462 is post-translationally phosphorylated at four serine residues and is in involved celluar adhesion. The gene encoding KIAA1462 maps to human chromosome 10, which contains over 800 genes and 135 million nucleotides, making up nearly 4.5% of the human genome. PTEN is an important tumor suppressor gene located on chromosome 10 and, when defective, causes a genetic predisposition to cancer development known as Cowden syndrome. The chromosome 10 encoded gene ERCC6 is important for DNA repair and is linked to Cockayne syndrome which is characterized by extreme photosensitivity and premature aging. Tetrahydrobiopterin deficiency and a number of syndromes involving defective skull and facial bone fusion are also linked to chromosome 10. As with most trisomies, trisomy 10 is rare and is deleterious.