Host: Rabbit

Target Protein: phospho-CHEK1 (Ser286)

IR: Immunogen Range:SE(p-S)PS

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 1111

Swiss Prot: O14757

Source: KLH conjugated Synthesised phosphopeptide derived from human CHEK1 around the phosphorylation site of Ser286:SE(p-S)PS 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2011].