Host: Rabbit
Target Protein: CIP29
IR: Immunogen Range:111-210/210
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 84324
Swiss Prot: P82979
Source: KLH conjugated synthetic peptide derived from human CIP29:111-210/210
Purification: affinity purified by Protein A
Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background: CIP29 is a 210 amino acid nuclear protein whose expression is upregulated by erythropoietin. Induction of CIP2 expression is associated with cell cycle progression and apoptosis. This transcription factor binds both single stranded (ss) and double stranded (ds) DNA, though it has higher affinity for ssDNA. CIP29 is expressed at low levels in pancreas, spleen, testis, liver, kidney, heart and thymus, and is found to be expressed at higher levels in pancreatic adenocarcinoma and hepatocellular carcinoma. A translocation t(11;12)(q23;q13) in acute myelomonocytic leukemia results in the coding region of CIP29 gene fused to exon 9 of the MLL gene, which encodes for a protein with the N-terminal SAP domain and two C-terminal nuclear localization signals of CIP29 and N-termial AT hooks and central DNA methyltransferase homology region of MLL.
Size: 200ul
Concentration: 1mg/ml
Applications: IHC-P=1:100-500, IHC-F=1:100-500, ICC=1:100-500, IF=1:100-500, ELISA=1:5000-10000
Cross Reactive Species: (predicted: Human,Mouse,Rat,Dog,Pig,Cow,Horse)
For research use only. Not intended for diagnostic or therapeutic use.