Host: Rabbit

Target Protein: phospho-Cortactin (Tyr421)

IR: Immunogen Range:PV(p-Y)ED

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 2017

Swiss Prot: Q14247

Source: KLH conjugated Synthesised phosphopeptide derived from human Cortactin around the phosphorylation site of Tyr421:PV(p-Y)ED 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010]