Host: Rabbit
Target Protein: JAML
IR: Immunogen Range:151-250/394
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 120425
Swiss Prot: Q86YT9
Source:
KLH conjugated synthetic peptide derived from human JAML:151-250/394
Purification: affinity purified by Protein A
Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background: JAML is a 394 amino acid single-pass type I membrane protein and novel adhesion molecule with localization at the cell plasma membrane in regions of cell-to-cell contact but not free cell borders, implying that JAML participates in homophilic interactions. JAML belongs to the immunoglobulin superfamily and is expressed in peripheral blood leukocytes, bone marrow, spleen, lymph nodes and fetal thymus, liver and spleen. JAML assists in the migration of leukocytes through endothelilal and epithelial tissues, mediates binding with CAR (coxsackie and adenovirus receptor) via its Ig-like V-type domain 2, and strengthens the binding of leukocytes to endothelial cells. Consisting of a transmembrane segment, cytoplasmic tail, 19-amino acid signal peptide and two extracellular immunoglobulin-like domains, JAML also undergoes alternative splicing resulting in three isoforms and is encoded by a gene mapping to human chromosome 11q23.3.
Size: 200ul
Concentration: 1mg/ml
Applications: IHC-P=1:100-500, IHC-F=1:100-500, ICC=1:100-500, IF=1:100-500, ELISA=1:5000-10000
Cross Reactive Species: (predicted: Human)
For research use only. Not intended for diagnostic or therapeutic use.