Host: Rabbit

Target Protein: PERK

IR: Immunogen Range:1001-1116/1116

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 9451

Swiss Prot: Q9NZJ5

Source: KLH conjugated synthetic peptide derived from human PERK:1001-1116/1116 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Jan 2010]