Host: Rabbit

Target Protein: LYPD1

IR: Immunogen Range:51-141/141

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 116372

Swiss Prot: Q8N2G4

Source: KLH conjugated synthetic peptide derived from human LYPD1:51-141/141 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: LYPD1 is a 141 amino acid protein that contains one UPAR/Ly6 domain. LYPD1 is a cell membrane protein expressed as three isoforms and encoded by a gene mapping to human chromosome 2. As the second largest human chromosome, chromosome 2 makes up approximately 8% of the human genome and contains 237 million bases encoding over 1,400 genes. A number of genetic diseases are linked to genes on chromosome 2. Harlequin icthyosis, a rare skin deformity, is associated with mutations in the ABCA12 gene. The lipid metabolic disorder sitosterolemia is associated with ABCG5 and ABCG8. An extremely rare recessive genetic disorder, Alstr鰉 syndrome, is related to mutations in the ALMS1 gene. Chromosome 2 contains a probable vestigial second centromere as well as vestigial telomeres, which gives credence to the hypothesis that human chromosome 2 formed as a result of an ancient fusion of two ancestral chromosomes, which are still present in modern day apes.