Host: Rabbit

Target Protein: MBLAC2

IR: Immunogen Range:2-100/279

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 153364

Swiss Prot: Q68D91

Source: KLH conjugated synthetic peptide derived from human MBLAC2:2-100/279 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: MBLAC2 is a 279 amino acid protein that belongs to the glyoxalase II family and metallo-β-lactamase superfamily. Existing as two alternatively spliced isoforms, MBLAC2 binds two zinc ions and is encoded by a gene that maps to human chromosome 5q14.3. Chromosome 5 contains 181 million base pairs and comprises nearly 6% of the human genome. Chromosome 5 is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumor suppressor gene. Treacher Collins syndrome is also chromosome 5-associated and is caused by insertions or deletions within the TCOF1 gene. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm or of chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.