Host: Rabbit

Target Protein: phospho-MDC1 (Ser964)

IR: Immunogen Range:AS(p-S)PT

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 9656

Swiss Prot: Q14676

Source: KLH conjugated synthesised phosphopeptide derived from human MDC1 around the phosphorylation site of Ser964:AS(p-S)PT 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq, Jul 2008]