Host: Rabbit

Target Protein: Naca

IR: Immunogen Range:121-215/215

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 17938

Swiss Prot: E9PAV3

Source: KLH conjugated synthetic peptide derived from human Alpha-NAC, muscle-specific form:121-215/215 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: NACA1, NACA2 and NACAP1 are members of the nascent polypeptide-associated complex (NAC) α subunit family that participate in preventing inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). As nascent polypeptide chains emerge from the ribosome, NACA proteins bind to these chains and block their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Members of the α-NAC subunit family have sequence similarities with transcription-regulating proteins and are suggested to function as transcriptional coactivators potentiating c-Jun-mediated transcription. Most NACA proteins localize to both nucleus as well as cytoplasm, and contain NAC-A/B (NAC-α/β) and UBA (ubiquitin-associated) domains. The UBA domain is associated with proteins involved in the ubiquitin-proteasome pathway for protein degradation.