Host: Rabbit

Target Protein: NMRAL1

IR: Immunogen Range:201-299/299

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 57407

Swiss Prot: Q9HBL8

Source: KLH conjugated synthetic peptide derived from human NMRAL1:201-299/299 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: HSCARG is a 299 amino acid redox sensor protein that belongs to the NmrA-type oxidoreductase family. Localizing primarily to the cytoplasm and perinuclear region, HSCARG localization to the nucleus may occur with increased intracellular nitric oxide and reduced NADPH/NADP+ ratios. Existing as a homodimer, HSCARG interacts with ASS1, inhibiting ASS1 activity in the presence of low NADPH/NADP+ ratios. HSCARG gets induced by nitric oxide, cGMP and proinflammatory cytokines. The gene encoding HSCARG maps to human chromosome 16p13.3 and mouse chromosome 16 A1. Overexpression of the gene encoding HSCARG results in increased cell viability.