Host: Rabbit

Target Protein: NOTO

IR: Immunogen Range:121-220/251

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 344022

Swiss Prot: A8MTQ0

Source: KLH conjugated synthetic peptide derived from human NOTO:121-220/251 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: Transcription regulator acting downstream of both FOXA2 and T during notochord development. Required for node morphogenesis. Is essential for cilia formation in the posterior notochord (PNC) and for left-right patterning; acts upstream of FOXJ1 and RFX3 in this process and is required for the expression of various components important for axonemal assembly and function. Plays a role in regulating axial versus paraxial cell fate.