Host: Rabbit

Target Protein: phospho-DAPK1 (Ser308)

IR: Immunogen Range:KQ(p-S)VR

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 1612

Swiss Prot: P53355

Source: KLH conjugated synthesised phosphopeptide derived from human DAP Kinase 1 around the phosphorylation site of Ser308:KQ(p-S)VR 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: DAPK1 expression is frequently lost in human carcinomas and B-cell leukemia, and lower levels of expression correlates with high rates of metastasis. The loss of DAPK expression provides a link between suppression of apoptosis and metastasis. DAPK1 is thought be involved in an early apoptotic checkpoint which eliminates premalignant cells from cancer formation. Studies in bladder cancer patients have also shown that hypermethylation of DAPK1 correlates to high recurrence rates and thus DAPK1 may be used as a prognostic marker. DAPK1 is also reportedly a molecular regulator of neuronal death in epilepsy.