Host: Rabbit
Target Protein: PRKACA
IR: Immunogen Range:1-100/351
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 5566
Swiss Prot: P17612
Source: KLH conjugated synthetic peptide derived from human cAMP Protein Kinase Catalytic subunit:1-100/351
Purification: affinity purified by Protein A
Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background: This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. Tissue-specific isoforms that differ at the N-terminus have been described, and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms. [provided by RefSeq, Jan 2015]
Size: 50ul
Concentration: 1mg/ml
Applications: IHC-P=1:100-500, ELISA=1:5000-10000
Cross Reactive Species: Human,Mouse (predicted: Rat,Dog,Pig,Cow,Rabbit,Sheep)
For research use only. Not intended for diagnostic or therapeutic use.