Host: Rabbit

Target Protein: phospho-RASGRP3 (Thr133)

IR: Immunogen Range:RV(p-T)QR

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 25780

Swiss Prot: Q8IV61

Source: KLH conjugated synthesised phosphopeptide derived from human RASGRP3 around the phosphorylation site of Thr133:RV(p-T)QR 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]