Host: Rabbit

Target Protein: phospho-Parkin (Ser65)

IR: Immunogen Range:QQ(p-S)IV

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 5071

Swiss Prot: O60260

Source: KLH conjugated synthesised phosphopeptide derived from human Parkin around the phosphorylation site of Ser65:QQ(p-S)IV 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support. [provided by RefSeq, Jul 2008]