Host: Rabbit

Target Protein: phospho-PLB (Ser16+Thr17)

IR: Immunogen Range:RA(p-S)(p-T)IE

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 5350

Swiss Prot: P26678

Source: KLH conjugated synthesised phosphopeptide derived from human PLB around the phosphorylation site of Ser16+Thr17:RA(p-S)(p-T)IE 

Purification: affinity purified by Protein A

Storage: Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure. [provided by RefSeq, Jul 2008].