Host: Rabbit
Target Protein: phospho-PLB (Ser16+Thr17)
IR: Immunogen Range:RA(p-S)(p-T)IE
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 5350
Swiss Prot: P26678
Source: KLH conjugated synthesised phosphopeptide derived from human PLB around the phosphorylation site of Ser16+Thr17:RA(p-S)(p-T)IE
Purification: affinity purified by Protein A
Storage: Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background: The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure. [provided by RefSeq, Jul 2008].
Size: 50ul
Concentration: 1mg/ml
Applications: WB=1:500-2000, ELISA=1:5000-10000
Cross Reactive Species: (predicted: Human,Mouse,Rat,Dog,Pig,Cow,Sheep)
For research use only. Not intended for diagnostic or therapeutic use.