Host: Rabbit

Target Protein: phospho-TGF beta Receptor II (Ser225)

IR: Immunogen Range:DR(p-S)DI

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 7048

Swiss Prot: P37173

Source: KLH conjugated synthesised phosphopeptide derived from human TGF beta Receptor II around the phosphorylation site of Ser225:DR(p-S)DI 

Purification: affinity purified by Protein A

Storage: Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]